Actelion says lung drug macitentan submitted in Europe
















ZURICH (Reuters) – Actelion has submitted heart and lung drug macitentan to European health regulators, the second major step for the drug the Swiss group is positioning as a viable successor to its current top seller.


“The European Medicines Agency will now start the formal review process,” Actelion said on Thursday. It plans to sell the drug under the brand name Opsumit.













Actelion, which submitted the treatment to the U.S. health regulator a month ago, issued data last month showing macitentan prolonged overall survival by more than a third in a clinical trial.


The company is banking on macitentan to replace top-seller Tracleer which, like macitentan, also treats pulmonary arterial hypertension (PAH) and currently accounts for around 90 percent of group sales. Tracleer goes off patent from 2015 and faces growing competition from Gilead’s Letairis.


Actelion is continuing to prepare macitentan submissions in Switzerland and major markets around the world, the company said.


(Reporting By Katharina Bart; Editing by Dan Lalor)


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Why Can’t India Feed Its People?
















It was 1958, my father was still a child, and India was running out of food. That year’s wheat crop had slumped by 15 percent, the rice harvest by 12 percent, and prices in the markets were soaring. Far from his village in eastern India, ships loaded with wheat were steaming toward the country, part of Dwight Eisenhower’s plan to sell surplus grains, tobacco, and dairy products to friendly countries. All India Radio gave daily updates on the convoys, and the army barricaded ports in Mumbai and Kolkata against the hungry crowds.


“It was this very coarse, red wheat,” says Narsingh Deo Mishra, a childhood friend of my father’s and now a local politician in Auar, their home village. “We were told it was meant for American pigs,” says Mishra. “Back then, we weren’t any better than American pigs. So we ate it. We ate it all, and we begged for more.”













My father, Dinesh, grew up during the toughest years in modern India’s history, a time of droughts and floods. At 18 he weighed about 40 kilograms (90 pounds). In a photograph taken at the time, his cheeks are sunken, his Adam’s apple is prominent, and his eyes bulge from a gaunt skull. As he grew into his teens and early adulthood, however, the Green Revolution took hold: The fields were sown with hybrid seeds and enriched with chemical fertilizers, enabling the country first to feed itself and later to sell its grain on the global markets. India is a generation removed from those “ship-to-mouth” days; fewer than 2 percent of Indians now go without two square meals a day, and far fewer still die of starvation.


And yet, in places like Auar, malnutrition persists. The vast majority of Indians, especially villagers, are suspended in nutritional purgatory—they eat enough to fill their stomachs but not enough to stay healthy. In the early 1970s the number of calories the average Indian ate began rolling backward. In 1973 villagers ate just under 2,300 calories a day, according to the National Sample Survey Office, a branch of the Ministry of Statistics and Programme Implementation. By 2010 that number had dropped to about 2,020, compared with the government floor of 2,400 a day to qualify for food aid. The mismatch manifests itself in some of the world’s worst health score cards: Half of all children younger than three years old in India weigh too little for their age; 8 in 10 are anemic.


During months of reporting on malnutrition in India, I spoke almost daily to my father, who had long since escaped Auar and now runs a national scientific research center in Kolkata, where I grew up. This June I returned by myself to the dusty, hot village of my father’s childhood, hoping to understand more. I drove about 800 kilometers (500 miles) southeast from New Delhi to Auar, deep in the heart of Uttar Pradesh state. The local district of Pratapgarh is in the poorest third of the country’s 640 districts, according to the government. I’d been to the village before—first as a child and again in 2000, when I was getting ready to leave for college in Virginia. My father, who wanted me to remember my family’s origins, stood out then from cousins and old friends in his starched white shirt and tailored trousers, no longer comfortable sitting cross-legged in the dust.


On that visit he pointed out the few reminders from his childhood. There was the elementary school built, according to family legend, with the proceeds from a single gold coin saved by a great-granduncle during years of toil in Burma in the 1920s; and there were the brick additions made to the mud house that belonged to my grandfather. By then the house was falling apart and emptied of family, who were now scattered in cities across India.


When I returned this year, I set up camp outside, sleeping on a borrowed cot under the mango trees my father climbed as a child. Although I hired a snake charmer to clear the ruins of the hut of its newest inhabitants, I worried that he may have done a less than perfect job. For the next two weeks I walked the dry, barren fields of the village, waiting like the locals for the rains that this year, at least, never fully came. I carried out a rudimentary survey, weighing children on a bathroom scale I’d brought, and spoke to the oldest people I could find, asking them to contrast their memories of long-ago meals to those they ate today. And for those two weeks I ate what the average poor and landless Indian villager could afford.
 
 
In some ways, Auar has kept pace with modern India. I counted about 60 motorbikes parked outside houses. And 400 or so of the village’s roughly 2,000 residents carry mobile phones, according to the local merchant who offered a recharging service for the equivalent of about 20¢, using car batteries he carried on the back of his bicycle. Auar has power now—sometimes. Every other day the electricity poles hum and spark for a couple of hours, bringing life to the television in the small village store and the handful of wells irrigating the fields of wealthier farmers. It’s a luxury, nonetheless: About 400 million Indians have no access to electricity at all.


In other ways, Auar is unchanged from my father’s time. There’s still no running water in most homes, and it takes dozens of cranks of a hand pump to fill each bucket of water. Every act of nature requires a 15-minute walk to a field where pigs root around in the remains of yesterday’s visit. In 38 of the 40 households I visited, I noted the teenagers’ ribs and the distended bellies and loose, stretchy skin of the toddlers, the first and most obvious symptoms of a diet sufficient in calories but lacking in protein. When it was first reported in 1935 in Ghana, doctors called this form of malnutrition kwashiorkor, taking the local word for the illness a child gets when it’s weaned too early because a new baby has arrived. In Auar the villagers had no name for it.


I tracked down Ghanshyam, the son of a laborer who had worked about two acres of land my grandfather owned. (Like many Indians, Ghanshyam goes by only his first name.) My father remembers the laborer’s wife picking up scraps from our family’s dinner and taking them home to her sons. “She would whisper to me to take larger servings and leave something for her children,” says my father. “Even now, I feel guilty—I never left enough.” Rakesh, his oldest brother, would leave as much as he could, my father says. “But I was young, I didn’t really think.”


Ghanshyam took me to his one-room mud-and-straw hut in the center of the village. Dressed in a torn shirt and lungi—a cloth wrapped around his waist—and barefoot, it was unclear whether he was one of the same children who grew up with my father. He couldn’t tell me his age. He was too young to recall, as my father did, the school holiday to commemorate a visit by Chinese Premier Zhou Enlai in 1956. But he did remember the short-lived friendship of India and China turning into a border dispute six years later. That might make him somewhere around 50 or 52.


Ghanshyam, to me, embodies India’s poor and malnourished. He owns no land, except for the plot on which his hut stood. He has tuberculosis, which infects about 2 million Indians every year, but he still scrabbles for work in the fields of landowners, making between $ 2.50 and $ 3.50 a day. When strong enough, he hitches a ride to the city of Pratapgarh, 45 minutes away, in search of construction work paying as much as $ 3.75 a day. On other days, Ghanshyam waits for villagers to come find him for odd jobs. A neighbor once paid him $ 1.50 to build a small roof. Another time, he spent four or five hours helping to clear a field of weeds and stones. He made 80¢ that day.


In recent weeks, Ghanshyam found only a few days’ work. The monsoon was late, so there was little to be done in the fields; construction had slowed in anticipation of those same rains, the life force of rural India. With that meager income, Ghanshyam supported his wife, Urmila Devi, two teenage sons, and the wife of an older son whom I never saw. When I asked what happened to his eldest, Ghanshyam looked away. Urmila, a quiet woman who rarely spoke to me unless her husband was nearby, later told me the son had gone to a city to look for work and never returned. He’d left behind two young boys—more mouths to feed on the days the boys didn’t spend at their maternal grandparents’ house.


Every evening, I gave Ghanshyam about 50¢, the amount the government set last year as the daily poverty line above which Indians no longer qualify for the most subsidized form of food aid. In exchange, his wife included me in their meals. Thus, I would eat as many Indians do. In the morning we drank small cups of watery tea with milk, sweetened with a nugget of jaggery, a hard candy made from unrefined cane sugar. In the afternoon we each ate three rotis, a heavy, unleavened bread, dipping them into a thin gruel of lentils and spice called dal. The rotis were thick, dry, and almost tasteless, made with the cheapest, coarsest grain available. The dal was watery, with the pulses settling to the bottom, far different from my mother’s dal, which was thick, rich with butter and ghee, and spiced carefully.


At night, before walking to the family’s home, I used a stick to shake a few sour mangoes from the trees. Urmila boiled them in the dal to add flavor, pouring the mixture over some boiled rice.


It had been a year, at least, since Ghanshyam last ate meat, eight months since he was able to catch fish in the nearby river, and six months since he’d had an egg, he told me. Later I showed photos of the meals to Rachita Singh, a nutritionist at the Saket Max Hospital in New Delhi. She estimated they would provide about 1,700 to 1,800 calories a day. Such a diet, heavy in cereals and other carbohydrates, is what most rural Indians eat. In 2010, according to India’s statistics ministry, 64 percent of the calories consumed by rural Indians came from cereals, about 9 percent from oils and fats, and less than 5 percent each from sugar and pulses such as the lentils we ate. Fruit, vegetables, meat, eggs, and fish together made up about 2.5 percent. By all counts—overall calories or nutrients—it’s a poor diet.
 
 
Auar, like most Indian villages I’ve visited, is actually a collection of hamlets scattered around a central body of water, usually a deep well or two. In Auar life centered on what the villagers generously called the river. More of a rivulet, it was too small to show up on my maps. Sluggish and dirty when I visited at the end of the dry season, it served a multitude of purposes along the narrow stretch that ran past the village. Upriver, where the water was thought to be cleaner, children would do back flips into it, and women brought their laundry, the gentle slapping of wet cloth on stones filling the air. Early in the morning, the few households that owned a buffalo or cow would bring them for a bath. Downriver from the village, around a quick bend, the bank was a squelching, stinking open toilet.


The hamlets, called bastis, are segregated mostly by caste or religion. Others are settlements of five or six huts belonging to members of the same family. Sixty-two years after India’s first constitution declared caste discrimination illegal, the system still dictates daily life and constrains opportunities for hundreds of millions of people.


My first day in the village, I was taken to the upper-caste basti to meet the village headman, a tall, broad-chested Brahmin named Vinod Upadhyay. I wanted him to know I’d be living in the village and asking questions. He offered me a plastic chair outside his two-story brick house, where a shiny motorcycle stood next to an electric water pump. A servant brought out tea and biscuits. After my first sip, I asked Upadhyay why he wasn’t joining me.


“When I eat with lower castes, it disagrees with my stomach,” he answered nonchalantly.


My father’s family was of a middling caste called the Kayastha—we had neither the land nor privileges of the Brahmin but were spared the humiliating poverty of the lowest castes. Our hamlet reflected that: In old photographs my father took during trips back to Auar, the mud hut had started to take the shape of a house—a small brick addition in the early 1970s, another expansion in the early 1980s. Our neighbor was a distant cousin, his neighbor another cousin. Our hamlet was a 10-minute walk from Ghanshyam’s, where the huts were smaller, packed closer together, sharing a single hand-pumped well.


My life in the village quickly fell into a pattern that in many ways has remained unchanged for centuries. Rising with the sun, my stomach already growling with hunger, I’d seek a secluded spot to empty my slowly cramping bowels. With little running water, and almost no indoor toilets, entire fields were open latrines. Women rose earlier still, defecating in the dark in the hope of some privacy. Open defecation is a national crisis for some 665 million Indians; soiled water and food supplies are a major contributor to the spread of pathogens that kill about 1,000 children a day from diarrhea, hepatitis, and other diseases.


I’d bathe under a hand-pumped well, pumping with one hand while trying to rub myself clean. At Ghanshyam’s home, Urmila would already be burning some dry twigs to boil our morning tea. Before the sun rose too high, I’d accompany Ghanshyam on his search for work.


One morning we hitched a ride to Pratapgarh, joining a group of day laborers waiting at a traffic intersection to be picked for work. Those with obvious skills—painters with their brushes and cans of turpentine; carpenters with their tools—were chosen first. Last were people like Ghanshyam, who had little to offer but their strength. I followed him to where about 20 men were working on the foundation for a family home. My offer of labor was refused—my city clothes, tinted glasses, and well-fed frame betrayed me as an outsider.


I watched Ghanshyam carry bricks for an hour, his pace slacking as the sun climbed. By 10 a.m. the temperature was 102F. When the foreman yelled at Ghanshyam for being too slow, I took his place, an unpaid substitute. We dug ditches and broke bricks to mix in the mortar. It had been a week since I’d migrated to the village diet, and by noon I was exhausted. The men around me had withered, too, their movements slower, their ribs glistening in the sun. Ghanshyam opened a lunch box, and we ate onions and rotis. We had drunk the dal while waiting to be picked for work.


The temperature climbed to 118F, and the workers talked the foreman into letting them rest in the shade a half-hour longer. For two more hours, Ghanshyam and I took turns laboring. Finally, at 4 p.m., the foreman handed out the wages: Ghanshyam pocketed $ 1.75 for both of us; the other men each earned $ 2.20. Ghanshyam’s tuberculosis had slowed him down too much; I had done little to help. In Auar, the cereal-laden meals sat heavily in my stomach, and I felt less hungry than I’d imagined I would. The most obvious impact was a constant sense of lethargy. I moved more slowly and took longer to recover from short bursts of labor like that at the construction site. My weight dropped about five pounds in the two weeks I lived in the village.


In the evening, my phone would light up around 7 p.m. with a text message from the Papa John’s (PZZA) in Delhi. For $ 11—or 22 times the government’s poverty line—I could order a medium pepperoni and cheese pizza, except it would be delivered to my air-conditioned apartment in a posh Delhi suburb, not to this sweaty, hungry corner of India. I dreamed often of that pizza.
 
 
Experts have argued about the reasons for India’s worsening nutrition without reaching a conclusion. Abhijit Banerjee, an economist at Massachusetts Institute of Technology’s Poverty Action Lab, once described it to me as the “million-dollar question.” In 2009 two economists, Angus Deaton, at Princeton University, and Jean Drèze, at the G.B. Pant Social Science Institute in Allahabad, just two hours from Auar, wrote a paper arguing that Indians were consuming fewer calories today than in the 1980s because they needed fewer calories. Poor Indians now had bicycles and got sick less often, they said, and that might solve the puzzle that has confounded economists studying Indian nutrition—falling calorie counts at a time of rising real incomes.


According to Deaton and Drèze, economists have seen this trend twice before, in post-Mao China in the 1980s and 1990s, and in Britain during the Industrial Revolution, from 1775 to 1850. Before I left for the village, I called Deaton. He was irritated that my questions focused only on calories; he believes the environment in which those calories are consumed and burned, and the manual labor the person has to endure, are equally important, if not more so. “I am not saying, for instance, that Indians are well-nourished,” he said. “What I am saying is that the fact that they are eating fewer calories doesn’t mean anything unless you know more about the rest of their lives.”


Following Ghanshyam around, I was less convinced by Deaton’s explanation. Deepankar Basu and Amit Basole, two University of Massachusetts economists, are also skeptical. In a draft paper published in July, they found that while Indian incomes have gone up, a rise in spending on other essential items, such as health care and transportation, means the amount of money left over for food has remained stagnant at a time of high inflation.


There’s little data to show that Indians have moved into less physically strenuous jobs. India has yet to experience the kind of industrial revolution seen in large parts of China that has freed an entire generation from the fields. Sixty-nine percent of the nation’s 1.2 billion people still live in the countryside, vs. 49 percent of China’s 1.3 billion. The lives of Ghanshyam and other villagers in Auar certainly seemed to need more than what 1,700 calories or even the government-recommended minimum intake of 2,400 calories could sustain. India’s state medical research council says workers doing moderate or heavy labor need 2,730 to 3,490 calories a day.


Some of the causes for the caloric mismatch are clear. Corruption, incompetence, and official indifference mean record stockpiles of grain rot in warehouses, and supplies meant for the poor are often stolen. As much as $ 14.5 billion worth of food in one conspiracy was looted by corrupt politicians over 10 years from my father’s state of Uttar Pradesh alone, according to court documents. India spends $ 14 billion a year to help feed those who can’t afford to buy rice or wheat in the market. Every year, the World Bank estimates, almost 40 percent of that aid simply falls through the cracks of a system of paper-and-thumbprint accounting, starving the poorest, most isolated Indians. Nor has an Indian politician embraced the problem of hunger the way Brazil’s Luiz Inácio Lula da Silva did in 2003 with his Zero Hunger program, or Ghana’s John Kufuor did when he was president in the first decade of the 2000s. Both managed to halve the number of hungry people in their countries in only a few years of focused governmental effort.


To be fair, while India has struggled to improve nutrition for the entire country, it has largely managed to end death by starvation. But to cure India of hunger would require the nation to be cured of all else that ails it—corruption, bureaucracy, poverty, caste differences, the Malthusian nightmare of having more people than it can employ. In essence, it may be that Indians are still hungry because India is not yet a fully functional country. My father takes a darker view. “Nobody cares,” he says.
 
 
Most days during my stay, Ghanshyam didn’t find work. We would lie in the shade, stoned in the heat, stirring only to swat away flies and move our cots with the shadows. Soon after sundown, the darkness was complete, and almost everybody would head to sleep.


I’d walk back to the ruins of my father’s old house and imagine his childhood. In short stories he’s published, my father recreates a bucolic life interrupted by misfortune—disease, the curses of slighted gypsy women, ghosts, and poachers. The stories echo his own childhood. He survived smallpox; his body is still scarred from the near-death experience. A sister, born underweight and listless, died of malnutrition at six months. She had been named Munni, Hindi for “our little girl.”


In 1964 my grandfather landed a job as a conductor for the state-owned Indian Railways and moved the entire family—my grandmother, three sons (two more came later), and three daughters—to the city of Allahabad in eastern Uttar Pradesh. In socialist India, a government job was perhaps the only way out of poverty. My grandfather leveraged his accomplishment with a relentless focus on educating his sons.


That urge was a relic of our caste beginnings. Without large tracts of land to cultivate, Kayasthas in Uttar Pradesh and the neighboring state of Bengal became a caste of peons—clerks, bookkeepers, minor functionaries for the local maharajahs. That emphasis on being able to read and write has left an imprint throughout my family’s known history, starting with the great-granduncle who spent his life’s savings to build the primary school my father studied in and which still educates the village’s children.


Hardship for my father didn’t end with the move to the city or with the ballooning shipments of American grain. New to the city, my father and his brothers stood in lines outside ration shops to get rice and wheat. Often, he remembers, the shops would run out of supplies before their turn.


At 14, my father won a National Merit Scholarship, an Indian government program designed to help poor, talented students in villages pay for their high school and early college educations. At 19, he read an ad in a newspaper for a job in Mumbai with the government’s science and research programs. He clipped the ad and stowed away on a train, in much the same way that millions of migrants seek a better life in Mumbai, Delhi, and Bangalore today. The interview went well, and he landed a job that allowed him to earn a Ph.D. in nuclear physics at what is now the University of Mumbai.


For my father, the years of lining up for food rations were over. His older brother, who studied engineering, had gotten a job with the government of Uttar Pradesh, and their combined incomes paid for the education of their younger brothers and the weddings of their sisters. That final leap, from poverty to the lower-middle class, was repeated by each of my uncles—the three remaining brothers also became engineers. My cousins and I were born into families that could easily afford food, and the deprivation of Auar became a memory, rarely discussed.


And yet, at family reunions, it’s clear that childhood hunger stalked our parents and their siblings into adulthood. My cousins and I tower over our uncles; I am 4 inches (10 centimeters) taller than my father. One cousin was an amateur boxer in the Indian Navy; another passed the rigorous physical training required to join the Indian intelligence service and is posted in the Himalayas. A single generation of good nutrition catapulted us into the top 10 percent of Indians for height and health.


In Auar, I felt like a giant, stooping through doorways, my feet dangling over the edge of my borrowed cot. At dusk I’d walk with Ghanshyam along the borders of the village. With me at least, Ghanshyam was a quiet man, miserly with his words. He mostly resisted my attempts to get him to share more than his most basic thoughts. One night, however, I asked him about his favorite meal, and he opened up. He told me he’d been happiest when planning his eldest son’s wedding. As the groom’s father, he was the most important guest, and he described at length the dinner thrown by the girl’s family. “Mutton korma, chicken curry, fish curry, naan, saag paneer (spinach cooked in cottage cheese), pulao (rice pilaf),” he listed, along with the desserts—a sweetened rice pudding called kheer; jalebis, or sweet, fried dough; and ice cream.


On my last day in the village, I drove to Pratapgarh and had a restaurant pack up that exact meal. That night under the mango trees, I threw a small banquet for Ghanshyam’s family and his neighbors. Thirteen of us sat under the biggest tree, and in the light of my car’s headlights, Ghanshyam and I shared a small bottle of local liquor made from a flower called mahua that he’d brought for the occasion. He laughed when I spat out my first sip, and I noticed for the first time that he had no teeth except for the front row.


About an hour after dinner, as I packed my gear for the trip back to Delhi, I heard a rustling behind me. I thought it was a stray dog going through the empty plates and Styrofoam boxes, and I turned on my flashlight to scare it away.


Instead, the beam lit up Urmila. She’d come back, she said, for the chicken bones I’d thrown away. For a family too poor to buy meat, even boiled-up bones make a valuable addition to the diet. “With some spices, it will taste just like chicken curry,” she said.


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Ivory Coast: New prime minister named
















ABIDJAN, Ivory Coast (AP) — President Alassane Ouattara has tapped Foreign Minister Daniel Kablan Duncan to serve as prime minister in a new government one week after the surprise dissolution of cabinet.


The appointment of Duncan, a member of the PDCI party of former President Henri Konan Bedie, was announced at a press conference Wednesday by Amadou Gon Coulibaly, general secretary of the presidency.













Ouattara dissolved the cabinet last week over a feud between his political party and the PDCI over proposed changes to the country’s marriage law.


The PDCI supported Ouattara in the November 2010 runoff election in exchange for the prime minister’s post, helping him defeat incumbent President Laurent Gbagbo. Gbagbo’s refusal to cede office led to five months of violence that claimed at least 3,000 lives before Ouattara’s forces won.


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BlackBerry maker wins vote of confidence ahead of BB10
















TORONTO (Reuters) – Research In Motion Ltd, for months enveloped by a wave of negative sentiment, got a boost on Tuesday when one of its most influential critics raised his rating on the stock ahead of the launch of RIM’s make-or-break new line of BlackBerry 10 devices.


The upgrade by Jefferies & Co analyst Peter Misek pushed RIM’s share price into double digits for the first time in five months, with the stock up more than 3 percent at $ 10.04 in early trading on the Nasdaq.













Misek based his more optimistic view of the BB10 launch, set for January 30, on a favorable reaction by telecom carriers to the devices and the new operating system that powers them.


“Preliminary results from our quarterly handset survey indicate developed market carriers have a much more positive view of BB10 than we expected,” Misek said in a note to clients.


Shares of Waterloo, Ontario-based RIM, a one-time leader in the smartphone industry, have plummeted in recent years as its aging line-up of devices lost ground to faster and snazzier devices from rivals. The company has bet its future on the new BB10.


RIM hopes BB10 smartphones will help claw back market share it has lost in recent years to Apple Inc’s iPhone and devices that run on Google Inc’s Android operating system.


Misek, who doubled his price target on shares of RIM to $ 10 from $ 5, also raised his rating on the stock to “hold” from “underperform”.


“With greater carrier shelf space and marketing support, we now believe BB10 has a 20 percent to 30 percent probability of success,” said Misek, who has long been skeptical of RIM’s odds of engineering a turnaround.


Misek cautioned that there is still downside if RIM’s gamble on BB10 fails, but he noted that the stock could be worth as much as $ 43 within the next 12 months if RIM’s bet pays off and its new operating system gets licensed by other handset makers.


RIM says its new devices will be faster and smoother and have a large catalog of applications, which are now critical to the success of any new line of smartphones. While feedback from both developers and carriers on the new devices has been largely upbeat, financial analysts have been much more circumspect about the company’s prospects.


Misek’s view is not shared by at least one of his counterparts.


In a note to clients on Monday, Pacific Crest analyst James Faucette reiterated his “underperform” rating on RIM’s shares. He said regardless of its quality, there is almost no chance that BB10 will meaningfully change RIM’s trajectory.


RIM shares were up 3.7 percent at $ 9.95 at midmorning on the Nasdaq, while its Toronto-listed shares rose 3.1 percent to C$ 9.89.


(Reporting by Euan Rocha; Editing by Jeffrey Benkoe; and Peter Galloway)


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One Direction’s 2nd CD hits No. 1, sells 540,000
















NEW YORK (AP) — One Direction‘s “Take Me Home” is the taking the boys to the top of the charts — and to new heights.


The group’s sophomore album has sold 540,000 in its first week, according to Nielsen SoundScan. It’s the year’s third-highest debut behind Taylor Swift‘s “Red,” which sold 1.2 million units its first week earlier this month, and Mumford & Sons’ “Babel,” which sold more than 600,000 albums in September in its debut week.













“We just want to say a massive thanks to all the fans who have supported us,” band member Harry Styles, 18, said in an interview Tuesday from London. “We can send tweets and thank them, but 140 characters is never going be enough to say how much it means.”


The album also debuted at No. 1 in the United Kingdom this week and is No. 1 in more than 30 countries, Columbia Records said Wednesday. The fivesome’s debut, “Up All Night,” came in at No. 2 in the United Kingdom last year; it was just released in March in America, where it hit No. 1 and has achieved platinum status.


“We were a little bit nervous about how people were going to take it,” 19-year-old Niall Horan said of the new album during tour rehearsals. “Everyone gets that second album syndrome.”


They say though they’re excited, they won’t be celebrating too much: “We’re finishing rehearsing soon and we’re going home to bed.”


One Direction, who placed third on the U.K. version of “The X Factor” in 2010, is signed to Simon Cowell’s Syco label imprint. In just a year, the band has become worldwide sensations, thanks to its feverish fans. They released a book and have a 3D movie planned. They also made the cut for Barbara Walters’ most fascinating people of 2012 list, which includes New Jersey Gov. Chris Christie and U.S. gold medalist Gabby Douglas.


One Direction says those experiences have helped the group mature.


“We’ve been working hard. We’re starting to grow up,” Horan said. “We’re still young, but we’ve passed the initial teenage years. …We’ve grown up quite quick in the job we have to do and we became a lot more independent.”


The group — which includes Zayn Malik, Liam Payne and Louis Tomlinson — will launch a worldwide tour in February. They hope to work with Katy Perry and are still trying to adjust to the celebrity and fame that has taken over their lives.


“I can see how it gets to people. I guess it’s quite easy to get wrapped up in it all,” Styles said. “We do the same things every other lad our age does. We go out, we have fun, we meet girls and stuff like that. Sometimes it gets written about, which, yeah, we think about it and it’s absolutely crazy. It’s still a bit weird thinking that that’s the way it is.”


___


Online:


http://www.onedirectionmusic.com/us/home/


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Xoma’s drug combo lowers high blood pressure in late-stage study
















(Reuters) – Xoma Corp said its experimental combination of two drugs met the main goal of lowering hypertension better than a treatment based on either of the drugs alone in a late-stage study, sending the biotechnology company‘s shares up 6 percent.


The combination of perindopril arginine and amlodipine besylate showed statistically significant reduction in sitting systolic and diastolic blood pressure after six weeks of treatment, compared with either drugs alone, Xoma said.













The company is likely to file a new drug application for the combination in 2013, said RBC Capital Markets analyst Adnan Butt.


Xoma said it does not plan to market the product directly but intends to sublicense it to a third party.


“The next thing we expect is for the company to get a partnership for this drug. The terms could include an upfront payment and possible royalties on product sales,” Butt said.


He added that the result would be a modest positive but the key driver is the company’s experimental anti-inflammatory drug gevokizumab. The drug is being tested in a late-stage study for treatment of non-infectious uveitis, an inflammation of the middle layer of the eye.


Xoma’s partner, French pharmaceutical company Les Laboratoires Servier, already markets the combination under the trade name Coveram in 91 countries outside the United States.


Perindopril and amlodipine each target different cardiovascular functions and are, therefore, used in combination to treat high blood pressure, Xoma said. The company bought the rights to Servier’s perindopril franchise in January.


The combination was well tolerated in the trial, and there were no serious adverse events, Xoma said.


Shares of the company rose to $ 2.84 in extended trade. They closed nearly 3 percent higher at $ 2.68 on Tuesday on the Nasdaq.


(Reporting By Vrinda Manocha in Bangalore; Editing by Sriraj Kalluvila)


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Asian shares, euro fall on uncertainty over Greek bailout
















TOKYO (Reuters) – The euro skidded on Wednesday and Asian shares fell after European officials failed to reach a deal on another bailout for Greece, a day after Federal Reserve Chairman Ben Bernanke highlighted the dangers of a U.S. fiscal crisis.


U.S. stock futures eased 0.4 percent, pointing to a weak Wall Street open.













Financial spreadbetters predict London’s FTSE 100 <.FTSE>, Paris’s CAC-40 <.FCHI> and Frankfurt’s DAX <.GDAXI> would open down as much as 0.2 percent, following weakness in Asia. <.L> <.EU> <.N>


The euro slumped 0.5 percent to $ 1.2752, extending losses and retreating from Tuesday’s two-week high of $ 1.28295.


The euro’s decline lifted the dollar up 0.3 percent against a basket of key currencies <.DXY> and weighed on commodities such as gold, which eased 0.3 percent to $ 1,722.70 an ounce.


Euro zone finance ministers and Greece’s international lenders will gather again on Monday. Their meeting in Brussels ended on Wednesday without an agreement on the next tranche of loans to Greece, as they haggled over myriad options on how to bring the country’s debt down to a sustainable level, without which emergency aid cannot be disbursed to Athens.


“The euro is being sold because markets had believed the ministers would agree on aid for Greece at today’s meeting,” said Yuji Saito, director of foreign exchange at Credit Agricole in Tokyo.


“Instead, a settlement is postponed, highlighting the difficulty of getting consensus on the debt crisis. But I feel this is a typical European political show and an agreement will be reached.”


The bearish news from Europe dragged down Asian shares, whose two-day rise had already been stalled after Bernanke on Tuesday repeated a warning that failure to avoid the $ 600 billion “fiscal cliff” in expiring tax cuts and government spending reductions could lead to recession in the United States.


The Fed chief said worries over how budget negotiations will be resolved were already damaging growth.


Concerns about the United States failing to raise its debt ceiling rattled financial markets in August 2011 and prompted Standard & Poor’s to cut the top-notch U.S. government bond rating for the first time ever.


“The price action suggests market participants are unclear of what to make of recent developments and therefore this warrants some caution,” said Stan Shamu, strategist at IG Markets.


But Hirokazu Yuihama, a senior strategist at Daiwa Securities, said that for all the concerns over the fiscal cliff, most of the market expected the U.S. Congress and White House to reach a compromise to avert the crisis.


MSCI’s broadest index of Asia-Pacific shares outside Japan <.MIAPJ0000PUS> slipped 0.2 percent. Hong Kong <.HSI> shares bucked the falling trend but pared earlier gains to rise 0.5 percent while Shanghai shares <.SSEC> inched up 0.3 percent.


Japan’s Nikkei stock average <.N225> closed up 0.9 percent at a two month-high as exporters were buoyed by a weaker yen.


The yen has come under pressure on expectations that a general election on December 16 will result in victory for an opposition leader who wants the Bank of Japan to aggressively ease monetary policy to stem the economy from further deterioration. <.T>


MACRO DATA EYED


Daiwa’s Yuihama said concerns over third-quarter earnings have subsided as most Asian companies had already reported results.


“This has prompted investors to turn to economic fundamentals. Signs of recovery in the U.S. and China are offering some assurances that the global economic slump may not be as severe as previously feared, even if growth remains fragile,” Yuihama said.


Investors will now focus on HSBC China flash PMI for November due on Thursday to see whether a low point for China, the world’s second largest economy, is over. U.S. manufacturing figures are due later on Wednesday while those from Europe are due on Thursday.


Trading activity was slowing ahead of the U.S. Thanksgiving long weekend.


Going into the holiday, the dollar has been underpinned broadly by data indicating a moderate U.S. recovery taking root, while the yen remained under pressure, with more data showing Japan‘s economy struggling.


Japan’s exports fell 6.5 percent in October from a year ago, dropping for a fifth consecutive month, weighed down by weakening global demand and a territorial row with China, its main customer.


In the U.S. on Tuesday, a report showed housing starts rose to the highest rate in more than four years in October.


The dollar rose to a 7-1/2-month high against the yen of 81.975 yen while the euro briefly touched a peak of 105.05 yen, its highest point since May 4.


A retreat in shares dragged oil lower, although prices remained supported by a lack of ceasefire between Israelis and Palestinians, which raised concerns about supply disruptions from the Middle East.


U.S. crude futures pared earlier gains and were up 0.1 percent to $ 86.85 a barrel by midafternoon, and Brent crude also trimmed earlier rises and was up 0.2 percent at $ 110.03.


Weak appetite for riskier assets also interest in Asian credit markets subdued, with the spreads on the iTraxx Asia ex-Japan investment-grade index tightening by 1 basis point.


(Additional reporting by Miranda Maxwell in Melbourne; Editing by Simon Cameron-Moore & Kim Coghill)


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AP Exclusive: Syrian rebels seize base, arms trove
















BASE OF THE 46TH REGIMENT, Syria (AP) — After a nearly two-month siege, Syrian rebels overwhelmed a large military base in the north of the country and made off with tanks, armored vehicles and truckloads of munitions that rebel leaders say will give them a boost in the fight against President Bashar Assad‘s army.


The rebel capture of the base of the Syrian army’s 46th Regiment is a sharp blow to the government’s efforts to roll back rebels gains and shows a rising level of organization among opposition forces.













More important than the base’s fall, however, are the weapons the rebels found inside.


At a rebel base where the much of the haul was taken after the weekend victory, rebel fighters unloaded half a dozen large trucks piled high with green boxes full of mortars, artillery shells, rockets and rifles taken from the base. Parked nearby were five tanks, two armored vehicles, two rocket launchers and two heavy-caliber artillery cannons.


Around 20 Syrian soldiers captured in the battle were put to work carrying munitions boxes, barefoot and stripped to the waist. Rebels refused to let reporters talk to them or see where they were being held.


“There has never been a battle before with this much booty,” said Gen. Ahmad al-Faj of the rebels Joint Command, a grouping of rebel brigades that was involved in the siege. Speaking on Monday at the rebel base, set up in a former customs office at Syria’s Bab al-Hawa border crossing with Turkey, he said the haul would be distributed among the brigades.


For months, Syria’s rebels have gradually been destroying government checkpoints and taking over towns in the northern provinces of Idlib and Aleppo along the Turkish border.


Rebel fighters say that weapons seized in such battles have been essential to their transformation from ragtag brigades into forces capable of challenging Assad’s professional army. Cross-border arms smuggling from Turkey and Iraq has also played a role, although the most common complaint among rebel fighters is that they lack ammunition and heavy weapons, munitions and anti-aircraft weapons to fight Assad’s air force.


It is unclear how many government bases the rebels have overrun during the 20-month conflict, mostly because they rarely try to hold captured facilities. Staying in the captured bases would make them sitting ducks for regime airstrikes.


“Their strategy is to hit and run,” said Elias Hanna, a retired Lebanese army general and Beirut-based strategic analyst. “They’re trying to hurt the regime where it hurts by bisecting and compartmentalizing Syria in order to dilute the regime’s power.”


The 46th Regiment was a major pillar of the government’s force near the northern city of Aleppo, Syria’s economic hub, and its fall cuts a major supply line to the regime’s army, Hanna said. Government forces have been battling rebels for months over control of Aleppo.


“It’s a tactical turning point that may lead to a strategic shift,” he said.


At the 46th Regiment’s base, about 25 kilometers (15 miles) west of Aleppo, the main three-story command building showed signs of the battle — its walls punctured apparently from rebel rocket attacks. The smaller barracks buildings scattered around the compound, about 2.6 square kilometers (1 square mile) in size, had been looted, with mattresses overturned. A number of buildings had been torched.


Reporters from The Associated Press who visited the base late Monday saw no trace of the government troops who had been defending it — other than the dead bodies of seven soldiers.


Two of them, in camouflage uniforms, lay outside the command building. One of them was missing his head, apparently blown off in an explosion.


The rest were in a nearby clinic. Four dead soldiers were on stretchers set on the floor, one with a large gash in his arm, another with what appeared to be a large shrapnel hole in the back of his head. The last lay on a gurney in another room, his arms and legs bandaged, a bullet hole in his cheek and a splatter of blood on the wall and ceiling behind him as if he had been shot where he lay.


It could not be determined how or when the soldiers had been killed.


The final assault that took the base came after more than 50 days of siege that left the soldiers inside demoralized, according to fighters who took part.


Working together and communicating by radio, a number of different rebels groups divided up the area surrounding the base and each cut the regime’s supply lines, said Abdullah Qadi, a rebel field commander. Over the course of the siege, dozens of soldiers defected, some telling the rebels that those inside were short of food, Qadi said.


The rebels decided to attack Saturday afternoon when they felt the soldiers inside were weak and the rebels had enough ammunition to finish the battle, Qadi said. The battle was over by nightfall on Sunday. Seven rebel fighters were killed in the battle, said al-Faj of the rebels’ Joint Command. Other rebel leaders gave similar numbers.


It remains unclear how many soldiers remained in the base when the rebels launched their attack and what happened to them.


Al-Faj said all soldiers inside were either killed or captured. He said he didn’t know how many were killed, but that the rebels had taken about 50 prisoners, all of whom would be tried in a rebel court. Aside from the 20 prisoners seen at the rebel’s Bab al-Hawa base, the AP was unable to see any other captured soldiers.


The Syrian government does not respond to requests for comment on military affairs and said nothing about the base’s capture. It says the rebels are terrorists backed by foreign powers that seek to destroy the country.


Disorganization has plagued the Syrian opposition since the start of the anti-Assad uprising in March 2011, with exile groups pleading for international help even when they have no control over those fighting inside of Syria.


A newly formed Syrian opposition coalition received a boost Tuesday, when Britain officially recognized it as the sole representative of the Syrian people.


The National Coalition of the Syrian Revolutionary and Opposition Forces was formed in the Gulf nation of Qatar on Oct. 11 under pressure from the United States for a stronger, more united opposition body to serve as a counterweight to more extremist forces.


British Foreign Secretary William Hague said Tuesday the body’s members gave assurances to be a “moderate political force committed to democracy” and that the West must “support them and deny space to extremist groups.”


The United States and the European Union have both spoken well of the body but stopped short of offering it full recognition.


Key to the body’s success will be its ability to build ties with the disparate rebel groups fighting inside Syria. Many rebel leaders say they don’t recognize the new body, and a group of extremist Islamist factions on Monday rejected it, announcing that they had formed an “Islamic state” in Aleppo.


Anti-regime activists say nearly 40,000 people have been killed since Syria’s crisis started 20 months ago.


___


Associated Press write Elizabeth Kennedy contributed reporting from Beirut, Lebanon.


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People turn to Twitter for CPR information: study
















(Reuters) – Amid snarky comments and links to cat videos, some Twitter users turn to the social network to find and post information on health issues like cardiac arrest and CPR, according to a U.S. study.


Over a month, researchers found 15,234 messages on Twitter that included specific information about resuscitation and cardiac arrest, said the study published in the journal Resuscitation.













“From a science standpoint, we wanted to know if we can reliably find information on a public health topic, or is (Twitter) just a place where people describe what they ate that day,” said Raina Merchant, the study’s lead author and a professor at the Department of Emergency Medicine at the University of Pennsylvania.


According to the researchers, they found people using Twitter to send and receive a wide variety of information on CPR and cardiac arrest, including their personal experiences, questions and current events.


Some researchers and organizations already use Twitter for public health matters, including tracking the 2009 H1N1 “swine flu” pandemic and finding the source of the Haitian cholera outbreak, the researchers said.


For the study, the researchers created a Twitter search for key terms, such as CPR, AED (automatic external defibrillators), resuscitation and sudden death.


Between April and May 2011, their search returned 62,163 tweets, which were whittled down to 15,324 messages that contained specific information about cardiac arrest and resuscitation.


Only 7 percent of the tweets were about specific cardiac arrest events, such as a user saying they just saw a man being resuscitated, or a user asking for prayers for a sick family member.


About 44 percent of the tweets were about performing CPR and using an AED. Those types of tweets included information on rules about keeping AEDs in businesses and questions about how to resuscitate a person.


The rest of the tweets were about education, research and news events, such as links to articles about celebrities going into cardiac arrest.


The vast majority of the Twitter users send fewer than three tweets about cardiac arrest or CPR throughout the month. Users that sent more tweets typically had more followers – people who subscribe to their messages – and often worked in a health-care related field.


About 13 percent of the tweets were re-sent, or retweeted, by other users. The most popular retweeted messages were about celebrity-related cardiac arrest news, such as an AED being used to revive a fan at a Lady Gaga concert.


“I think the pilot (study) illustrated for us that there is an opportunity to potentially provide research and information for people in real time about cardiac arrest and resuscitation,” Marchant said.


“I can imagine in the future we will see systems that would automatically respond to tweets of individual users. Twitter is a really powerful tool, and we’re just beginning to understand its abilities.”


SOURCE: http://bit.ly/T2bj7u


(Reporting from New York by Andrew Seaman at Reuters Health; editing by Elaine)


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Pharmacies Dispense Meds Even After Docs Stop Prescription
















Image courtesy of iStockphoto/monkeybuisnessimages

When doctors take patients off of a prescription medicine, it is often for a good reason. But pharmacists don’t always get the memo. A new study finds that more than 1 in 100 discontinued prescriptions were filled by the pharmacy anyway, putting some patients at serious risk. In the U.S., pharmacists filled more than 3.7 trillion prescriptions in 2011. With so many prescriptions and refills–and our still largely human- and paper-based prescribing system–there are bound to be mistakes. Pharmacists may overlook drug interactions, dispense inappropriate medications, or commit other little-understood errors. One such underappreciated problem area is the process of taking patients off medication. While errors in initial prescribing have drawn much attention, potential for error when doctors order a prescription to stop also looms large. And electronic health records, which have helped to minimize medical errors in other areas, might be partly to blame. These electronic communiqu?s might be giving some doctors–and patients–a false sense of efficacy. Doctors might assume that when they make a note on a patient’s electronic health record to stop a prescription the pharmacy will automatically get the message as it does when they first prescribed that medication. This, however, is not always the case, wrote Adrienne Allen, of the North Shore Physician Group, and Thomas Sequist, of Brigham and Women’s Hospital in the new paper, published online November 19 in Annals of Internal Medicine. To find out how often the pharmacies continue to dispense meds the doctor no longer ordered, Allen and Sequist analyzed electronic health records of 30,406 adults in a Massachusetts health system whose doctor had discontinued a drug to treat a high-risk condition such as high cholesterol, hypertension, diabetes, blood coagulation or platelet aggregation. Some 83,900 medications were discontinued during the course of a year. Nevertheless, pharmacists still dispensed 1,218 of these prescriptions after they were discontinued. The most common drug that pharmacists dispensed after a doctor canceled the prescription was metoprolol (Lopressor or Toprol), which is often prescribed to treat high blood pressure after a heart attack and which can have harmful drug interactions with other commonly prescribed drugs. In a subset of medical records, a computer analysis flagged more than a third (34 percent) of the improper dispensations as creating a “high risk of potential adverse events” such as a harmful reaction, potential drug interaction or suspect lab test result, the researchers noted. And manual assessment verified that potential harm actually occurred in at least 12 percent of cases. Patients receiving these drugs were more likely to be taking more medications, older, enrolled in Medicare and black. Additional medications make it more likely that a patient will suffer an adverse drug interaction if they take an unintended prescription (especially if a doctor has subsequently prescribed a similar drug to take the discontinued drug’s place). And older adults might be less likely to notice a mistake. One limitation of the study is that the researchers could only study the 52 percent of discontinued prescriptions that were filled at participating health care system pharmacies; unaffiliated pharmacies might have even higher inappropriate dispensation rates. Additionally, the researchers only studied a limited number of drugs. Adding other drugs to the analysis would likely increase the number of discontinued prescriptions dispensed, even if the risk of side effects might be lower. They researchers see promise for filling this communication gap in the future. Electronic health records offer an opportunity to track these missteps, and adding more direct communication with pharmacies about prescription discontinuation should help avoid these errors. For now, however, the new technology is often not as powerful as many doctors think it is. So some of the responsibility will continue to lie with the patient. Officials would be wise to help “increase patient awareness of their medication list,” the researchers concluded. That is, until the computers can just do it for us.












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